S100A1: Another Step Toward Therapeutic Development for Heart Failure
نویسندگان
چکیده
منابع مشابه
S100A1: Another Step Toward Therapeutic Development for Heart Failure.
It has been nearly 130 years since Sydney Ringer’s astute observations on the indispensability of extracellular Ca to eart muscle contraction (1). At the cellular level, we now now that fluctuations of cytosolic Ca are coordinated by everal myocyte proteins in order to functionally couple the ardiac action potential to sarcomeric shortening and mitohondrial energy production. This elegant myoca...
متن کاملToward Heart Failure After Myocardial Infarction Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity
Andrew Remppis, Sven T. Pleger, Brent R. DeGeorge, Jr, Andrea D. Eckhart, Arthur M. Patrick Most, Hanna Seifert, Erhe Gao, Hajime Funakoshi, Mirko Völkers, Jörg Heierhorst, Toward Heart Failure After Myocardial Infarction Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2006 American Heart Association, Inc. ...
متن کاملCardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
BACKGROUND Diminished cardiac S100A1 protein levels are characteristic of ischemic and dilated human cardiomyopathy. Because S100A1 has recently been identified as a Ca2+-dependent inotropic factor in the heart, this study sought to explore the pathophysiological relevance of S100A1 levels in development and progression of postischemic heart failure (HF). METHODS AND RESULTS S100A1-transgenic...
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in order to improve the quality of education in universities of medical sciences (ums), and because of the key role of education development centers (edcs), an accreditation scheme was developed to evaluate their performance.a group of experts in the medical education field was selected based on pre-defined criteria by edc of ministry of health and medical education. the team, worked intensivel...
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S pontaneous mutation, the occurrence of random changes in the nucleotide sequences, is an unavoidable result of the basic laws of nature and the key property of DNA. Together with natural selection, mutation is a sine qua non of evolution, and the genome of a species can be thought of as a record of mutations, beneficial, neutral, or very slightly deleterious, that became fixed, over a very lo...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2011
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2011.04.032